| 14.03.2013 | CCL | Santos Laguna | 3-0 | Houston Dynamo | |
| 06.03.2013 | CCL | Houston Dynamo | 1-0 | Santos Laguna |
| GP | W | D | L | GF | GA | +/- | |
| home | 6 | 2 | 2 | 2 | 4 | 6 | -2 |
| away | 6 | 2 | 1 | 3 | 7 | 8 | -1 |
| total | 6 | 1 | 1 | 4 | 7 | 12 | -5 |
| Santos Laguna win | 50.00% | 1 |
| draw | % | 0 |
| Santos Laguna lose | 50.00% | 1 |
| GP | W | D | L | GF | GA | +/- | |
| home | 6 | 3 | 1 | 2 | 7 | 6 | 1 |
| away | 6 | 2 | 1 | 3 | 8 | 9 | -1 |
| total | 6 | 2 | 2 | 2 | 7 | 5 | 2 |
| Houston Dynamo win | 50.00% | 1 |
| draw | % | 0 |
| Houston Dynamo lose | 50.00% | 1 |
| 20.05.2013 | D1PO | Cruz Azul | 2-1 | Santos Laguna | ![]() |
| 17.05.2013 | D1PO | Santos Laguna | 0-3 | Cruz Azul | ![]() |
| 13.05.2013 | D1PO | Club Atlas | 1-3 | Santos Laguna | ![]() |
| 10.05.2013 | D1PO | Santos Laguna | 0-0 | Club Atlas | ![]() |
| 05.05.2013 | D1 | Santos Laguna | 1-2 | Monarcas Morelia | ![]() |
| 02.05.2013 | CCL | CF Monterrey | 4-2 | Santos Laguna | ![]() |
| 19.05.2013 | D1 | Houston Dynamo | 0-2 | New England Revolution | ![]() |
| 13.05.2013 | D1 | Houston Dynamo | 0-1 | Sporting Kansas City | ![]() |
| 09.05.2013 | D1 | DC United | 0-4 | Houston Dynamo | ![]() |
| 06.05.2013 | D1 | Los Angeles Galaxy | 0-1 | Houston Dynamo | ![]() |
| 28.04.2013 | D1 | Houston Dynamo | 1-1 | Colorado Rapids | ![]() |
| 20.04.2013 | D1 | Toronto FC | 1-1 | Houston Dynamo | ![]() |
| over 2.5 | 52.08% | 25 |
| under 2.5 | 47.92% | 23 |
| over 2.5 | 45.16% | 14 |
| under 2.5 | 54.84% | 17 |
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