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| 22.02.2026 | D1 | Club León | 2-1 | Santos Laguna | |
| 19.10.2025 | D1 | Santos Laguna | 2-0 | Club León | |
| 10.03.2025 | D1 | Santos Laguna | 2-1 | Club León | |
| 25.08.2024 | D1 | Club León | 1-1 | Santos Laguna | |
| 28.01.2024 | D1 | Club León | 3-2 | Santos Laguna | |
| 27.11.2023 | D1PO | Club León | 3-2 | Santos Laguna |
| GP | W | D | L | GF | GA | +/- | |
| home | 6 | 3 | 0 | 3 | 9 | 9 | 0 |
| away | 6 | 0 | 1 | 5 | 4 | 12 | -8 |
| total | 6 | 2 | 0 | 4 | 7 | 11 | -4 |
| Leon win | 47.06% | 16 |
| draw | 17.65% | 6 |
| Leon lose | 35.29% | 12 |
| GP | W | D | L | GF | GA | +/- | |
| home | 6 | 2 | 1 | 3 | 9 | 10 | -1 |
| away | 6 | 1 | 1 | 4 | 7 | 17 | -10 |
| total | 6 | 1 | 1 | 4 | 8 | 14 | -6 |
| Santos Laguna win | 35.29% | 12 |
| draw | 17.65% | 6 |
| Santos Laguna lose | 47.06% | 16 |
| 07.03.2026 | D1 | Mazatlán FC | 4-2 | Club León |  |
| 01.03.2026 | D1 | Club León | 2-1 | Club Necaxa |  |
| 22.02.2026 | D1 | Club León | 2-1 | Santos Laguna | |
| 15.02.2026 | D1 | CF Monterrey | 1-0 | Club León | |
| 08.02.2026 | D1 | Querétaro FC | 2-0 | Club León | |
| 01.02.2026 | D1 | Club León | 1-2 | Tigres UANL | |
| 09.03.2026 | D1 | Club Tijuana | 1-2 | Santos Laguna | |
| 04.03.2026 | D1 | Santos Laguna | 1-2 | Cruz Azul | |
| 28.02.2026 | D1 | Querétaro FC | 2-2 | Santos Laguna |  |
| 22.02.2026 | D1 | Club León | 2-1 | Santos Laguna | |
| 16.02.2026 | D1 | Santos Laguna | 1-2 | Mazatlán FC | |
| 07.02.2026 | D1 | Tigres UANL | 5-1 | Santos Laguna | |
| over 2.5 | 51.85% | 14 |
| under 2.5 | 48.15% | 13 |
| over 2.5 | 68.57% | 24 |
| under 2.5 | 31.43% | 11 |
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