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| 28.02.2026 | D1 | Querétaro FC | 2-2 | Santos Laguna | |
| 27.10.2025 | D1 | Santos Laguna | 3-1 | Querétaro FC | |
| 14.04.2025 | D1 | Santos Laguna | 1-2 | Querétaro FC | |
| 09.11.2024 | D1 | Querétaro FC | 3-2 | Santos Laguna | |
| 02.03.2024 | D1 | Querétaro FC | 0-1 | Santos Laguna | |
| 03.07.2023 | D1 | Santos Laguna | 0-2 | Querétaro FC |
| GP | W | D | L | GF | GA | +/- | |
| home | 6 | 2 | 2 | 2 | 7 | 6 | 1 |
| away | 6 | 1 | 1 | 4 | 5 | 14 | -9 |
| total | 6 | 1 | 2 | 3 | 5 | 11 | -6 |
| Queretaro win | 29.16% | 14 |
| draw | 22.92% | 11 |
| Queretaro lose | 47.92% | 23 |
| GP | W | D | L | GF | GA | +/- | |
| home | 6 | 2 | 1 | 3 | 9 | 10 | -1 |
| away | 6 | 1 | 1 | 4 | 7 | 17 | -10 |
| total | 6 | 1 | 1 | 4 | 8 | 14 | -6 |
| Santos Laguna win | 47.91% | 23 |
| draw | 22.92% | 11 |
| Santos Laguna lose | 29.17% | 14 |
| 08.03.2026 | D1 | Querétaro FC | 1-2 | Club América |  |
| 05.03.2026 | D1 | CF Monterrey | 4-0 | Querétaro FC | |
| 28.02.2026 | D1 | Querétaro FC | 2-2 | Santos Laguna |  |
| 23.02.2026 | D1 | Querétaro FC | P-P | FC Juárez |  |
| 15.02.2026 | D1 | Atlético San Luis | 3-0 | Querétaro FC | |
| 08.02.2026 | D1 | Querétaro FC | 2-0 | Club León |  |
| 09.03.2026 | D1 | Club Tijuana | 1-2 | Santos Laguna | |
| 04.03.2026 | D1 | Santos Laguna | 1-2 | Cruz Azul | |
| 28.02.2026 | D1 | Querétaro FC | 2-2 | Santos Laguna | |
| 22.02.2026 | D1 | Club León | 2-1 | Santos Laguna | |
| 16.02.2026 | D1 | Santos Laguna | 1-2 | Mazatlán FC | |
| 07.02.2026 | D1 | Tigres UANL | 5-1 | Santos Laguna | |
| over 2.5 | 59.38% | 19 |
| under 2.5 | 40.62% | 13 |
| over 2.5 | 68.57% | 24 |
| under 2.5 | 31.43% | 11 |
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