United States
| 02.09.2010 | USA Cup | DC United | 1-2 AET | Columbus Crew | ![]() |
| 28.08.2010 | USA D1 | Columbus Crew | 0-0 | FC Dallas | ![]() |
| 25.08.2010 | CNCF CCL | Santos Laguna | 1-0 | Columbus Crew | ![]() |
| 22.08.2010 | USA D1 | Columbus Crew | 3-1 | Colorado Rapids | ![]() |
| 19.08.2010 | CNCF CCL | Columbus Crew | 1-0 | CSD Municipal | ![]() |
| 15.08.2010 | USA D1 | Real Salt Lake | 2-0 | Columbus Crew | ![]() |
| 05.09.2010 | USA D1 | DC United | - | Columbus Crew | |
| 12.09.2010 | USA D1 | Los Angeles Galaxy | - | Columbus Crew | |
| 14.09.2010 | CNCF CCL | Columbus Crew | - | Joe Public FC | |
| 18.09.2010 | USA D1 | Columbus Crew | - | Seattle Sounders | |
| 21.09.2010 | CNCF CCL | Columbus Crew | - | Santos Laguna | |
| 26.09.2010 | USA D1 | New England Revolution | - | Columbus Crew |
| Pos. | Team | GP | Pts | W | D | L | GF | GA | +/- |
| 1 | Los Angeles Galaxy | 22 | 43 | 13 | 4 | 5 | 32 | 16 | 16 |
| 2 | Columbus Crew | 22 | 41 | 12 | 5 | 5 | 31 | 20 | 11 |
| 3 | Real Salt Lake | 22 | 40 | 11 | 7 | 4 | 36 | 16 | 20 |
| 4 | FC Dallas | 21 | 37 | 9 | 10 | 2 | 28 | 17 | 11 |
| 5 | New York Red Bulls | 22 | 37 | 11 | 4 | 7 | 27 | 23 | 4 |
| 6 | Seattle Sounders | 22 | 32 | 9 | 5 | 8 | 25 | 26 | -1 |
| 7 | Colorado Rapids | 21 | 31 | 8 | 7 | 6 | 25 | 21 | 4 |
| 8 | San Jose Earthquake | 20 | 29 | 8 | 5 | 7 | 22 | 22 | 0 |
| 9 | Toronto FC | 21 | 27 | 7 | 6 | 8 | 22 | 25 | -3 |
| 10 | Kansas City Wizards | 21 | 26 | 7 | 5 | 9 | 21 | 23 | -2 |
| 11 | Chicago Fire | 19 | 24 | 6 | 6 | 7 | 27 | 28 | -1 |
| 12 | Houston Dynamo | 22 | 23 | 6 | 5 | 11 | 27 | 36 | -9 |
| 13 | CD Chivas USA | 21 | 22 | 6 | 4 | 11 | 23 | 26 | -3 |
| 14 | New England Revolution | 21 | 21 | 6 | 3 | 12 | 21 | 35 | -14 |
| 15 | Philadelphia Union | 21 | 20 | 5 | 5 | 11 | 25 | 37 | -12 |
| 16 | DC United | 22 | 15 | 4 | 3 | 15 | 15 | 36 | -21 |
| over 2.5 | 40.74% | 11 |
| under 2.5 | 59.26% | 16 |
| yes | 48.15% | 13 |
| no | 51.85% | 14 |
| yes | 40.74% | 11 |
| no | 59.26% | 16 |
| 1-15 | 7.69% | 3 |
| 16-30 | 7.69% | 3 |
| 31-45 | 28.21% | 11 |
| 46-60 | 12.82% | 5 |
| 61-75 | 7.69% | 3 |
| 76-90 | 33.33% | 13 |
| 2.57% | 1 |
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